VISDB Viral Integration Site DataBase

VIS ID

TVIS10007513

Fusion event

HBV-DENND1B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2014

Orient

+

Integrated sequence

CCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGT| |ATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTG

Chromosome

chr1

Cytoband

q31.3

Reference genome

Start

End

197681762/197712632 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-6869-5p ; hsa-mir-155-5p ; hsa-mir-4312 ; hsa-mir-532-5p ; hsa-mir-802 ; hsa-mir-365b-3p ; hsa-mir-365a-3p ; hsa-mir-195-3p

Nearest miRNA

hsa-mir-101-1/Upstream/1130151; hsa-mir-1182/Downstream/1146241;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/511043, chr1-CpG: 103/Downstream/62169

Upstream sequence

tagaaagctgaaactggatcccttccttacaccttatacaaaaatcaattcaagatggattaaagatttaaacgttagacctaaaaccataaaaacccta

Downstream sequence

gaagaaaacctaggcattaccattcaggacataggagtgggcaaggacttcatgtccaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaat