Basic Information
VIS ID
TVIS10007519
Fusion event
HBV-CLCA4-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2081
Orient
+
Integrated sequence
TACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCT| |TTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATG
Host Sequence
Chromosome
chr1
Cytoband
p22.3
Reference genome
GRCh37/hg19
Start
87145954/86680271 (Hg38)
End
87145954/86680271 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1D
Target gene
CLCA4-AS1
Nearest miRNA
hsa-mir-101-1/Upstream/322584; hsa-mir-11399/Downstream/7166561;
Nearest TSS
ENST00000473358/Upstream/109155; ENST00000602603/Downstream/12932;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/126778, chr1-CpG: 125/Downstream/23921
Nearby gene
CLCA3P(-24895) ; SH3GLB1(+24299) ;
Upstream sequence
aatggtaatgcctaggttttcttctagggtttttatggttttaggtttaacgtttaaatctttaatccatcttgaattgatttttgtataaggtgtaagg
Downstream sequence
aagagatccagtttcagctttctacatatggctagccagttttcccagcaccatttattaaatagggaatcctttccccattgcttgtttttctcaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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