Basic Information
VIS ID
TVIS10007522
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr10
Cytoband
q25.2
Reference genome
GRCh37/hg19
Start
113348542/111588784 (Hg38)
End
113348542/111588784 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/599771; hsa-mir-202/Downstream/710828;
Nearest TSS
ENST00000439456/Upstream/236681; ENST00000643850/Downstream/594926;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/509239, chr10-CpG: 35/Downstream/594741
Nearby gene
ADRA2A(-507880) ; GPAM(+561080) ;
Upstream sequence
aggattccctatttaataaatggtgctgggaaaactggctagccatatgtagaaagctgaaactgggtcccttccttacaccttatacaaaaatcaattc
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate