hsa-mir-130b-3p _LIHC.png
ATE1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007524
Fusion event
HBV-ATE1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2260
Orient
-
Integrated sequence
AGTTATGTCAACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGG| |TGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGG
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
123645273/121885758 (Hg38)
End
123645273/121885758 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
ATE1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-107/Upstream/1927166; hsa-mir-202/Downstream/531207;
Nearest TSS
ENST00000439456/Upstream/95532; ENST00000618971/Downstream/16780;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/276539, chr10-CpG: 125/Downstream/41699
Upstream sequence
aaggcaggcaggcaggcggatcacttgagtccagagttcctgaccaggttggccaacatggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gcttggagtcatgcgcctgtagtcctagctacttgggaggctgaagcacgagaatcgcttgaacctgggaggtggttgttgcagtgaatcgagattgtgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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