Basic Information
VIS ID
TVIS10007525
Fusion event
HBV-chr10 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2373
Orient
+
Integrated sequence
GTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGA| |AGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAG
Host Sequence
Chromosome
chr10
Cytoband
p13
Reference genome
GRCh37/hg19
Start
13259658/13217658 (Hg38)
End
13259658/13217658 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-3155a/Upstream/492305; hsa-mir-107/Downstream/1165542;
Nearest TSS
ENST00000439456/Upstream/18895; ENST00000448272/Downstream/16673;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/55868, chr10-CpG: 84/Downstream/81719
Nearby gene
MCM10(-6554) ; UCMA(+4109) ;
Upstream sequence
gttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttcatgtccaaaacaccaaaagcaa
Downstream sequence
tggcaacaaaagccaaaattgacaaatgggatctaattaaactaaagagcttctgcacagcaaaagaaactaccatcagagtgaacaggcaacctacaac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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