VISDB Viral Integration Site DataBase

VIS ID

TVIS10007528

Fusion event

HBV-NEBL integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2326

Orient

-

Integrated sequence

ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG

Chromosome

chr10

Cytoband

p12.31

Reference genome

Start

End

21307815/21018886 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-7856-5p ; hsa-mir-4477b ; hsa-mir-4684-5p ; hsa-mir-6892-5p ; hsa-mir-942-5p ; hsa-mir-7845-5p ; hsa-mir-4475 ; hsa-mir-6507-3p ; hsa-mir-6883-3p ; hsa-mir-3156-3p ; hsa-mir-324-5p ; hsa-mir-3162-3p ; hsa-mir-4301 ; hsa-mir-140-3p

Nearest miRNA

hsa-mir-1265/Upstream/466840; hsa-mir-107/Downstream/477676;

Nearest TSS

Nearest CpG islands

None/Target, chr10-CpG: 68/Upstream/1200869, chr10-CpG: 149/Downstream/154313

Upstream sequence

tgggaggccgaggcaggtggatcacaaagtcaggagttcaagaccagcctgaccaagatggtgaaaccctgtccctactaaaaatacaaaaattagccgg

Downstream sequence

gtgtggtagcaggcgcctgtaatcccagctattggggaggctgaggcagagaactgcgtgaagccgggaggcagaggttgcagtgagccgagacggcacc