Basic Information
VIS ID
TVIS10007533
Fusion event
HBV-LOC105369466 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1992
Orient
+
Integrated sequence
GCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTT| |CTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGG
Host Sequence
Chromosome
chr11
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
104547187/104676459 (Hg38)
End
104547187/104676459 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105369466
Nearest miRNA
hsa-mir-10392/Upstream/826479; hsa-let-7a-2/Downstream/6671298;
Nearest TSS
ENST00000527297/Upstream/67138; ENST00000527177/Downstream/270733;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/512129, chr11-CpG: 31/Downstream/933940
Nearby gene
PDGFD(-512160) ; CASP12(+209258) ;
Upstream sequence
cctgttcactctgatggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggt
Downstream sequence
gttttggacatgaagtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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