Basic Information
VIS ID
TVIS10007534
Fusion event
HBV-chr11 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2081
Orient
+
Integrated sequence
TACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCT| |TTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATG
Host Sequence
Chromosome
chr11
Cytoband
q25
Reference genome
GRCh37/hg19
Start
130812377/130942482 (Hg38)
End
130812377/130942482 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7a-2/Upstream/275679; hsa-mir-4697/Downstream/2956022;
Nearest TSS
ENST00000527297/Upstream/25973; ENST00000441665/Downstream/244540;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/25743, chr11-CpG: 16/Downstream/747980
Nearby gene
SNX19(-25995) ; NTM(+427994) ;
Upstream sequence
aatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaagtctttaatccatcttgaattaatttttgtataaggtgtaagg
Downstream sequence
aagggatccagtttcagctttctacatatggctagccagttttcccagcaccatttattaaatagggaatcctttccccattgtttgtttttctcaggtt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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