VISDB Viral Integration Site DataBase

VIS ID

TVIS10007542

Fusion event

HBV-HEPHL1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1958

Orient

+

Integrated sequence

CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT

Chromosome

chr11

Cytoband

q21

Reference genome

Start

End

93774890/94041724 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-607 ; hsa-mir-4639-5p ; hsa-mir-489-3p ; hsa-mir-3671 ; hsa-mir-5591-3p ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-668-3p ; hsa-mir-1273g-3p ; hsa-mir-3680-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-3910 ; hsa-mir-3714 ; hsa-mir-4777-5p ; hsa-mir-526a ; hsa-mir-523-5p ; hsa-mir-522-5p ; hsa-mir-520c-5p ; hsa-mir-519c-5p ; hsa-mir-519b-5p ; hsa-mir-519a-5p ; hsa-mir-518f-5p ; hsa-mir-518e-5p ; hsa-mir-518d-5p ; hsa-mir-8067 ; hsa-mir-6508-5p ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-203a-3p ; hsa-mir-223-5p ; hsa-mir-4698 ; hsa-mir-8063

Nearest miRNA

hsa-mir-10392/Upstream/307960; hsa-let-7a-2/Downstream/424771;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/191173, chr11-CpG: 19/Downstream/47211

Upstream sequence

aggattccctatttaataaatggtgctgggaaaactggatagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaatcaattc

Downstream sequence

aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc