Basic Information
VIS ID
TVIS10007546
Fusion event
HBV-LOC105370060 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2780
Orient
+
Integrated sequence
TTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATATTAT| |ATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTC
Host Sequence
Chromosome
chr12
Cytoband
q24.32
Reference genome
GRCh37/hg19
Start
127178458/126693912 (Hg38)
End
127178458/126693912 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12E
Target gene
LOC105370060
Nearest miRNA
hsa-let-7i/Upstream/1778253; hsa-mir-3612/Downstream/1600180;
Nearest TSS
ENST00000382841/Upstream/3431; ENST00000535118/Downstream/32358;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/502263, chr12-CpG: 83/Downstream/32320
Nearby gene
LINC02347(-221127) ; LINC00944(+36789) ;
Upstream sequence
caatgagataccatctcaaccagttagaatggagatcattaaaaagtcaggaaacaacaggtgctggagaggatgtggagaaataggaacacttttacac
Downstream sequence
tgtttgtggaactgtaaactagttcaaccattgtggaagtcagtgtggcgattcctcagggatctagaactagaaataccatttgacccagccatcccat
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate