Basic Information
VIS ID
TVIS10007547
Fusion event
HBV-chr12 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|
Start
3020
Orient
+
Integrated sequence
AGCAAACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACC| |CCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAG
Host Sequence
Chromosome
chr12
Cytoband
q24.33
Reference genome
GRCh37/hg19
Start
133841520/133264934 (Hg38)
End
133841520/133264934 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA12E
Nearest miRNA
hsa-let-7i/Upstream/682873;
Nearest TSS
ENST00000382841/Upstream/28839;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/28418, None/Downstream
Nearby gene
ANHX(-29098) ;
Upstream sequence
CAGCAATGAAAATAGTCAACATAATAACCCTAAtagtgttagggttagggtcagggtcccggtccgggtcggggtccgggtccggggtccgggtcagggt
Downstream sequence
gagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagggttagg
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate