DIP2B _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007548
Fusion event
HBV-DIP2B integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr12
Cytoband
q13.12
Reference genome
GRCh37/hg19
Start
51025170/50631387 (Hg38)
End
51025170/50631387 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
DIP2B
Nearest miRNA
hsa-mir-1244-3/Upstream/397175; hsa-let-7i/Downstream/2267502;
Nearest TSS
ENST00000382841/Upstream/126280; ENST00000546719/Downstream/9418;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/126006, chr12-CpG: 139/Downstream/132328
Upstream sequence
ccagacttggctcactgcaacctctacctcctgggttcaagcaattctcctgcctcagcctcccgagtagctgagattacaggcacctgccaccacactc
Downstream sequence
ggctaatttttgtatttttagtagggacagggtttcaccatgttggccaggatggtctcgatctcttgacctcatgatccacctgcctcggcctcccaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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