Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007550
Fusion event
HBV-SRGAP1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr12
Cytoband
q14.2
Reference genome
Start
End
64241384/63847604 (Hg38)
Orient
+
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-214-3p ; hsa-mir-335-5p ; hsa-mir-1-3p ; hsa-mir-744-5p ; hsa-mir-92b-5p ; hsa-mir-181a-5p ; hsa-mir-1273e ; hsa-mir-6811-5p ; hsa-mir-6511b-5p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-8082 ; hsa-mir-6086 ; hsa-mir-4534 ; hsa-mir-377-5p ; hsa-mir-219b-3p ; hsa-mir-3664-3p ; hsa-mir-6746-5p ; hsa-mir-1247-3p ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4802-5p ; hsa-mir-510-5p ; hsa-mir-512-5p ; hsa-mir-302f ; hsa-mir-1273f ; hsa-mir-4768-3p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-7856-5p ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-8074 ; hsa-mir-4685-3p ; hsa-mir-4287 ; hsa-mir-1250-3p ; hsa-mir-1306-5p ; hsa-mir-3161 ; hsa-mir-7843-3p ; hsa-mir-203a-3p ; hsa-mir-4448 ; hsa-mir-4786-3p ; hsa-mir-4293 ; hsa-mir-6796-3p ; hsa-mir-99b-3p ; hsa-mir-99a-3p
Nearest miRNA
hsa-let-7i/Upstream/23877; hsa-mir-1178/Downstream/774905;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/2983, chr12-CpG: 54/Downstream/374440
Upstream sequence
gcactttgggagaccgaggtgggcggatcacttgaggccgagaccagcctggccaacatggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
acatggtggtgcatgcctgtagtcccagctaccctggaggctgagtcaggagaattgcttgaacccgggaggcagaagttgcagtgagctgaaattgcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.