Basic Information
VIS ID
TVIS10007553
Fusion event
HBV-B3GLCT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1959
Orient
+
Integrated sequence
TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG| |CCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATA
Host Sequence
Chromosome
chr13
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
31881344/31307207 (Hg38)
End
31881344/31307207 (Hg38)
Orient
+
Location type
Intronic
Target gene
B3GLCT
Nearest miRNA
hsa-mir-2276/Upstream/7144703; hsa-mir-1267/Downstream/8356827;
Nearest TSS
ENST00000623511/Upstream/46800; ENST00000622001/Downstream/112782;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/106310, chr13-CpG: 70/Downstream/539286
Upstream sequence
tgggaaaactggctagccatatgtagaaagctgaaactggatcccttccttacaccttatacaaaaatcaattcaagatggattaaagatttaaacgtta
Downstream sequence
gacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttcatgtccaaaacaccaaaagcaatggc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate