Basic Information
VIS ID
TVIS10007555
Fusion event
HBV-TRA integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2382
Orient
-
Integrated sequence
CACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACT| |CCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAAC
Host Sequence
Chromosome
chr14
Cytoband
q11.2
Reference genome
GRCh37/hg19
Start
22580262/22112309 (Hg38)
End
22580262/22112309 (Hg38)
Orient
+
Location type
Intronic
Target gene
TRA
Nearest miRNA
hsa-mir-6717/Upstream/1088923; hsa-mir-1185-1/Downstream/844641;
Nearest TSS
ENST00000550708/Upstream/6966; ENST00000390454/Downstream/38;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/600752, chr14-CpG: 40/Downstream/476706
Nearby gene
OR4E2(-446024) ; DAD1(+453545) ;
Upstream sequence
CAGGGGGGCAGCATCGGCAAACATAGACTCTCCTCTGAGAGGGTGGGCAAAATAGTGTGATTGGTTTTCTCAACTTGCAGTCACCTCTTTCCCTTTCTTT
Downstream sequence
CCAAAATGCACACATCTACTTTCCAAAATAGACCGCAACTATTTCTATTGATCTGGAAGAAGCTTGTACCAGGCAACCCATTTAGGAGAAGTTGGATGAA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate