VISDB Viral Integration Site DataBase

VIS ID

TVIS10007559

Fusion event

HBV-MAP2K1 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2018

Orient

+

Integrated sequence

ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG

Chromosome

chr15

Cytoband

q22.31

Reference genome

Start

End

66743577/66451239 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-424-5p ; hsa-mir-34a-5p ; hsa-mir-1826 ; hsa-mir-497-5p ; hsa-mir-128-3p ; hsa-mir-181a-5p ; hsa-mir-101-3p ; hsa-mir-93-3p ; hsa-mir-30c-5p ; hsa-mir-142-5p ; hsa-mir-559 ; hsa-mir-548b-5p ; hsa-mir-548a-5p ; hsa-mir-548c-5p ; hsa-mir-548d-5p ; hsa-mir-548j-5p ; hsa-mir-548k ; hsa-mir-548l ; hsa-mir-548h-5p ; hsa-mir-548i ; hsa-mir-548w ; hsa-mir-548y ; hsa-mir-548o-5p ; hsa-mir-548ab ; hsa-mir-548ad-5p ; hsa-mir-548ae-5p ; hsa-mir-548ak ; hsa-mir-548am-5p ; hsa-mir-451b ; hsa-mir-548ap-5p ; hsa-mir-548aq-5p ; hsa-mir-548ar-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-5590-3p ; hsa-mir-548av-5p ; hsa-mir-548ay-5p ; hsa-mir-6507-5p ; hsa-mir-8054 ; hsa-mir-548bb-5p ; hsa-mir-624-5p ; hsa-mir-181b-5p ; hsa-mir-494-3p ; hsa-mir-34c-5p ; hsa-mir-34b-3p ; hsa-mir-449a ; hsa-mir-448 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-889-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p

Nearest miRNA

hsa-mir-10393/Upstream/410907; hsa-mir-11181/Downstream/45719;

Nearest TSS

Nearest CpG islands

None/Target, chr15-CpG: 55/Upstream/63614, chr15-CpG: 32/Downstream/46356

Upstream sequence

caagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggactt

Downstream sequence

catgtccaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaatgggatctaattaaactcaagagcttctgcacagcaaaagaaactaccatc