Basic Information
VIS ID
TVIS10007560
Fusion event
HBV-LINC02253 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2373
Orient
+
Integrated sequence
GTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGA| |AGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAG
Host Sequence
Chromosome
chr15
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
97809849/97266619 (Hg38)
End
97809849/97266619 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC02253
Nearest miRNA
hsa-mir-10393/Upstream/933312; hsa-mir-1302-10/Downstream/1517807;
Nearest TSS
ENST00000557528/Upstream/483132; ENST00000560314/Downstream/29262;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/849318, chr15-CpG: 32/Downstream/386172
Nearby gene
SPATA8(-481004) ; LINC00923(+475997) ;
Upstream sequence
tgtaggttgcctgttcactctgatggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccatt
Downstream sequence
gcttttggtgttttggacatgaagtccttgcccgcgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgt
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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