Basic Information
VIS ID
TVIS10007565
Fusion event
HBV-LOC100506083 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2323
Orient
-
Integrated sequence
CTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTAT| |CAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAG
Host Sequence
Chromosome
chr16
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
70372449/70338546 (Hg38)
End
70372449/70338546 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA16B
Target gene
LOC100506083
Nearest miRNA
hsa-mir-1225/Upstream/308124; hsa-mir-11401/Downstream/6530390;
Nearest TSS
ENST00000527434/Upstream/39212; ENST00000565195/Downstream/8283;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/48960, chr16-CpG: 39/Downstream/8190
Upstream sequence
tgtatttttagtagagatggggtttcaccatgttggccaaggtcttgaacttctgacctcaggtgatccgcctgccgtgtataggcgtgagccaccatac
Downstream sequence
acggctaatttttgtatttttagtagggacggggtttcaccatgttggccagaccggtctcgaactcctggcctcaagcgagcaactcacctcggcctcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate