VISDB Viral Integration Site DataBase

VIS ID

TVIS10007567

Fusion event

HBV-TUBB3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2326

Orient

-

Integrated sequence

ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG

Chromosome

chr16

Cytoband

q24.3

Reference genome

Start

End

89995531/89929123 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-200c-3p ; hsa-mir-193b-3p ; hsa-mir-340-5p ; hsa-mir-30a-5p ; hsa-mir-16-5p ; hsa-mir-505-3p ; hsa-mir-92a-3p

Nearest miRNA

hsa-mir-11401/Upstream/1212786;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/2571, chr16-CpG: 30/Downstream/4820

Upstream sequence

ttgatctcagctcactgcaacctctgccccctgggttcaagcgattctcgtgtctcagactctgaaacaactgaaattacaggtgcgcgctaccacgccc

Downstream sequence

ggctaatttttgtatttttagtagggacagggttttgccctgttgtccaggttggtcctgaactcctgacttcaagtgatctgcctgcctcagcctccca