Basic Information
VIS ID
TVIS10007568
Fusion event
HBV-LOC101927026 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr16
Cytoband
p13.2
Reference genome
GRCh37/hg19
Start
9679413/9585556 (Hg38)
End
9679413/9585556 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC101927026
Nearest miRNA
hsa-mir-1225/Upstream/3952990; hsa-mir-11401/Downstream/1720884;
Nearest TSS
ENST00000527434/Upstream/43511; ENST00000636913/Downstream/91287;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/492724, chr16-CpG: 282/Downstream/594530
Nearby gene
MIR548X(-350610) ; GRIN2A(+167852) ;
Upstream sequence
atggtagtttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatga
Downstream sequence
agtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate