Basic Information
VIS ID
TVIS10007580
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr19
Cytoband
p13.12
Reference genome
GRCh37/hg19
Start
14321571/14210759 (Hg38)
End
14321571/14210759 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA19B
Nearest miRNA
hsa-mir-10395/Upstream/137280; hsa-let-7e/Downstream/318784;
Nearest TSS
ENST00000633603/Upstream/4572; ENST00000588275/Downstream/58618;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/927, chr19-CpG: 26/Downstream/38064
Nearby gene
ADGRL1(-4574) ; ADGRE5(+170385) ;
Upstream sequence
ttatttattttgaggagtctcgctctgttgcccaggatggagtgcagtggcacgatctctgctcactgcaacctccctctcccgggttcaagtgatttcc
Downstream sequence
ggctaatttttgtatttttagtagggacagggtttcaccatgttggctaggctggtctcgaactcctgacctcaagtgatccgcccacctcggcctccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate