Basic Information
VIS ID
TVIS10007584
Fusion event
HBV-chr19 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr19
Cytoband
q13.42
Reference genome
GRCh37/hg19
Start
54900979/54389375 (Hg38)
End
54900979/54389375 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA19A
Nearest miRNA
hsa-let-7e/Upstream/107195; hsa-mir-10394/Downstream/255934;
Nearest TSS
ENST00000633603/Upstream/18817; ENST00000462769/Downstream/25844;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/181868, chr19-CpG: 54/Downstream/25854
Nearby gene
LAIR1(-24258) ; TTYH1(+25626) ;
Upstream sequence
tcggaaggccgaggcaggtggatcacctgaggtgagttcgagaccagccttaccaacaaggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gcgtggtggctggcgcctgtagtcccagctactcgggaggctaaggcaggagaattccttgaacccgcgaggtggaggttgcagtgagccgagatcgtgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate