Basic Information
VIS ID
TVIS10007590
Fusion event
HBV-LOC105373696 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr2
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
155846245/154989733 (Hg38)
End
155846245/154989733 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105373696
Nearest miRNA
hsa-mir-128-1/Upstream/3621322; hsa-mir-10b/Downstream/4197102;
Nearest TSS
ENST00000437798/Upstream/21730; ENST00000416888/Downstream/1034843;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/290176, chr2-CpG: 82/Downstream/1330006
Nearby gene
KCNJ3(-131381) ; NR4A2(+1334699) ;
Upstream sequence
tggtaatttcttttgctgtgcagaagctctttagtttaattagatcccatttgtcaattttggcttttgttgccattgcttttggtgttttggacatgaa
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate