Basic Information
VIS ID
TVIS10007594
Fusion event
HBV-chr2 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr2
Cytoband
q36.1
Reference genome
GRCh37/hg19
Start
223012861/222148142 (Hg38)
End
223012861/222148142 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10b/Upstream/2241577; hsa-mir-1244-1/Downstream/2862319;
Nearest TSS
ENST00000437798/Upstream/510599; ENST00000440903/Downstream/73268;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/573921, chr2-CpG: 41/Downstream/142865
Nearby gene
EPHA4(-575851) ; PAX3(+51745) ;
Nearest cancer related gene
PAX3(OG, +51745) ;
Upstream sequence
caagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggactt
Downstream sequence
catgtccaaaacaccaaaagcaatggcaaccaaagccaaaattgacaaatgggatctaattaaactaaagagcttctgcacagcaaaagaaactaccatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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