Basic Information
VIS ID
TVIS10007600
Fusion event
HBV-CAMKMT integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2269
Orient
-
Integrated sequence
AACACTAATATGGGCCTAAAGTTCAGGCAACTCTTGTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCG| |GAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCC
Host Sequence
Chromosome
chr2
Cytoband
p21
Reference genome
GRCh37/hg19
Start
44643874/44416735 (Hg38)
End
44643874/44416735 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CAMKMT
miRNAs that regulate target gene
hsa-mir-26b-5p
Nearest miRNA
hsa-mir-1301/Upstream/8945249; hsa-mir-10b/Downstream/2960940;
Nearest TSS
ENST00000437798/Upstream/43987; ENST00000477830/Downstream/259859;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/54516, chr2-CpG: 19/Downstream/351790
Upstream sequence
tgatcttggctcactgcaacctgtgcctcctgggttcaagtgattctccctgcctcagcctcctaagtagctgtgattacaggtgcccacaaccacaccc
Downstream sequence
ggctaatttttgtatttttagtagggacagggtttcactatgttggccaggctggtctctaactcctaacctcaggtgatccacccgcctcagcctccca
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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