Basic Information
VIS ID
TVIS10007602
Fusion event
HBV-CLHC1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr2
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
55429550/55202414 (Hg38)
End
55429550/55202414 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
CLHC1
Nearest miRNA
hsa-mir-1301/Upstream/1353209; hsa-mir-10b/Downstream/780553;
Nearest TSS
ENST00000437798/Upstream/89793; ENST00000463185/Downstream/7238;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/151506, chr2-CpG: 53/Downstream/20969
Upstream sequence
ggagaccgaggtgtgcggatcacctgaggtcaggagttcgagatcagcctgatcaacatggagaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gcctggtggcaggtgcctgtaatcccaggtactcgggaggctgaggcaggagaattgcttgaacccaggaggcggagtttgcagtgagctgagatcgcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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