Basic Information
VIS ID
TVIS10007604
Fusion event
HBV-chr20 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1959
Orient
+
Integrated sequence
TACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTG| |CCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATA
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
12782760/12802112 (Hg38)
End
12782760/12802112 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/2152417; hsa-mir-1-1/Downstream/5668503;
Nearest TSS
ENST00000382410/Upstream/485627; ENST00000432244/Downstream/133671;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/910553, chr20-CpG: 217/Downstream/417911
Nearby gene
BTBD3(-875517) ; SPTLC3(+206867) ;
Upstream sequence
ttagtttaattagatcccatttgtcaattttggcttttgttgccattgtttttggtgttttggacatgaagtccttgcccacgcctatgtcctgaatggt
Downstream sequence
aatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaattgatttttgtataaggtgtaaggaaggga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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