Basic Information
VIS ID
TVIS10007608
Fusion event
HBV-LINC01273 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr20
Cytoband
q13.13
Reference genome
GRCh37/hg19
Start
48791579/50175042 (Hg38)
End
48791579/50175042 (Hg38)
Orient
-
Location type
Intronic
Target gene
LINC01273
Nearest miRNA
hsa-mir-103a-2/Upstream/311089; hsa-mir-1-1/Downstream/410744;
Nearest TSS
ENST00000382410/Upstream/2452; ENST00000303004/Downstream/15692;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/20870, chr20-CpG: 263/Downstream/15019
Nearby gene
TMEM189-UBE2V1(-21244) ; CEBPB(+15541) ;
Upstream sequence
acaatttcggctcacagcaacctctgcctcccgggttcaagcgattcccctgtctccgcctcccgagtagctgggattacaggcgcccaccaccacgccc
Downstream sequence
ggctaatttttgtatttttagtagggacagggtttcaccatgttggccaggctggtcttgaactcctggcctcgtgatccacccgccttggcctctcaaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate