Basic Information
VIS ID
TVIS10007614
Fusion event
HBV-chr22 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2319
Orient
-
Integrated sequence
TTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATC| |CTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTC
Host Sequence
Chromosome
chr22
Cytoband
q12.2
Reference genome
GRCh37/hg19
Start
31553686/31157700 (Hg38)
End
31553686/31157700 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA22B
Nearest miRNA
hsa-mir-1286/Upstream/426059; hsa-let-7a-3/Downstream/2362;
Nearest TSS
ENST00000624155/Upstream/17093; ENST00000468921/Downstream/2483;
Nearest CpG islands
None/Target, chr22-CpG: 279/Upstream/49815, chr22-CpG: 29/Downstream/2438
Nearby gene
PLA2G3(-17217) ; MIR3928(+2362) ;
Upstream sequence
gaagcccaaggtgggaggaacaccttaggtcaggagttcgagaccagcctggccaacatggtgaaaccctgtccctactaaaaatacaaaaattagccgg
Downstream sequence
gagtgatggtgggcgcctgtaatcccagctacttgggaggctgaggcagaagaatcacttgaacccaggaggcagaggctgcagtgagccgagatcacac
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate