VISDB Viral Integration Site DataBase

VIS ID

TVIS10007615

Fusion event

HBV-TNRC6B integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|Polymerase|

Start

2326

Orient

-

Integrated sequence

ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG

Chromosome

chr22

Cytoband

q13.1

Reference genome

Start

End

40698495/40302491 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-183-5p ; hsa-mir-7-5p ; hsa-mir-103a-3p ; hsa-mir-32-5p ; hsa-mir-21-5p ; hsa-mir-19b-3p ; hsa-mir-18a-5p ; hsa-mir-16-5p ; hsa-mir-1229-3p ; hsa-mir-744-5p ; hsa-mir-484 ; hsa-mir-320a ; hsa-mir-125b-5p ; hsa-mir-23b-3p ; hsa-mir-222-3p ; hsa-mir-99a-5p ; hsa-mir-31-5p ; hsa-let-7b-5p ; hsa-mir-18b-5p ; hsa-mir-26a-5p ; hsa-mir-26b-5p ; hsa-mir-1297 ; hsa-mir-4465 ; hsa-mir-5697 ; hsa-mir-29b-1-5p ; hsa-mir-362-3p ; hsa-mir-329-3p ; hsa-mir-603 ; hsa-mir-543 ; hsa-mir-3658 ; hsa-mir-3941 ; hsa-mir-6757-3p ; hsa-mir-8485 ; hsa-mir-19a-3p ; hsa-mir-1249-5p ; hsa-mir-6797-5p ; hsa-mir-4269 ; hsa-mir-3150b-3p ; hsa-mir-4784 ; hsa-mir-6715b-5p ; hsa-mir-520g-3p ; hsa-mir-520h ; hsa-mir-548at-5p ; hsa-mir-1321 ; hsa-mir-4739 ; hsa-mir-4756-5p ; hsa-mir-561-3p ; hsa-mir-6756-5p ; hsa-mir-6766-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-15b-5p ; hsa-mir-186-3p ; hsa-mir-195-5p ; hsa-mir-378a-5p ; hsa-mir-330-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-4310 ; hsa-mir-4729 ; hsa-mir-6838-5p ; hsa-mir-7157-5p ; hsa-mir-17-5p ; hsa-mir-20a-5p ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-106b-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-891b ; hsa-mir-5586-5p ; hsa-mir-6849-3p ; hsa-mir-4781-3p ; hsa-mir-3120-3p ; hsa-mir-148a-3p ; hsa-mir-130a-3p ; hsa-mir-152-3p ; hsa-mir-301a-3p ; hsa-mir-130b-3p ; hsa-mir-148b-3p ; hsa-mir-454-3p ; hsa-mir-301b-3p ; hsa-mir-4295 ; hsa-mir-3666 ; hsa-mir-3688-3p ; hsa-mir-4643 ; hsa-mir-506-3p ; hsa-mir-124-3p ; hsa-mir-5186 ; hsa-mir-1-5p ; hsa-mir-4753-5p ; hsa-mir-513a-5p ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-101-5p ; hsa-mir-3151-5p ; hsa-mir-6721-5p ; hsa-mir-486-3p ; hsa-mir-4722-5p ; hsa-mir-1286 ; hsa-mir-6804-5p ; hsa-mir-4692 ; hsa-mir-4514 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-1825 ; hsa-mir-759 ; hsa-mir-500b-3p ; hsa-mir-4482-5p ; hsa-mir-3130-5p ; hsa-mir-6515-5p ; hsa-mir-7847-3p ; hsa-mir-7106-5p ; hsa-mir-765 ; hsa-mir-766-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6127 ; hsa-mir-6129 ; hsa-mir-4510 ; hsa-mir-4419a ; hsa-mir-1252-5p ; hsa-mir-6876-5p ; hsa-mir-4476 ; hsa-mir-5089-5p ; hsa-mir-5589-5p ; hsa-mir-6807-5p ; hsa-mir-4731-5p ; hsa-mir-6506-5p ; hsa-mir-619-5p ; hsa-mir-512-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302c-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-3653-3p ; hsa-mir-299-5p ; hsa-mir-4511 ; hsa-mir-548b-3p ; hsa-mir-6863 ; hsa-mir-210-3p ; hsa-mir-4776-5p ; hsa-mir-3619-3p ; hsa-mir-3654 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-2682-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p ; hsa-mir-548c-3p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-6875-3p ; hsa-mir-744-3p ; hsa-mir-6868-3p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-5096 ; hsa-mir-3187-3p ; hsa-mir-4435 ; hsa-mir-588 ; hsa-mir-4701-5p ; hsa-mir-548s ; hsa-mir-197-3p ; hsa-mir-6131 ; hsa-mir-4755-3p ; hsa-mir-302a-5p ; hsa-mir-3663-5p ; hsa-mir-3653-5p ; hsa-mir-627-3p ; hsa-mir-4742-5p ; hsa-mir-4433a-3p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-1197 ; hsa-mir-4436a ; hsa-mir-4459 ; hsa-mir-4519 ; hsa-mir-4779 ; hsa-mir-5000-3p ; hsa-mir-92a-2-5p ; hsa-mir-129-5p ; hsa-mir-2113 ; hsa-mir-329-5p ; hsa-mir-4464 ; hsa-mir-4748 ; hsa-mir-5010-3p ; hsa-mir-6509-5p

Nearest miRNA

hsa-mir-1286/Upstream/2313638; hsa-let-7a-3/Downstream/511392;

Nearest TSS

Nearest CpG islands

None/Target, chr22-CpG: 279/Upstream/256685, chr22-CpG: 31/Downstream/43908

Upstream sequence

tgggaggctgaggcaggcagatcacgaggtcaggagatcgagaccagcctggccaatgtagtgaaaccctgtccctactaaaaatacaaaaattagccgg

Downstream sequence

acgttgtggcatgcgcctctaatcccagctactggggaggctgaggcaggagaatcacttgaacccgggagacggaggttgcagtgagctgagattgtgc