Basic Information
VIS ID
TVIS10007616
Fusion event
HBV-chr3 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|Polymerase|
Start
2326
Orient
-
Integrated sequence
ACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAA| |CACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAG
Host Sequence
Chromosome
chr3
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
10130827/10089143 (Hg38)
End
10130827/10089143 (Hg38)
Orient
+
Location type
Intronic
Target gene
FANCD2 ; FANCD2OS
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-769-5p ; hsa-mir-505-3p ; hsa-mir-331-3p ; hsa-let-7b-5p ; hsa-mir-6870-3p ; hsa-mir-759 ; hsa-mir-34c-3p ; hsa-mir-618
Nearest miRNA
hsa-mir-4790/Upstream/4838888; hsa-let-7g/Downstream/191208;
Nearest TSS
ENST00000440867/Upstream/3315; ENST00000470028/Downstream/4145;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/62562, chr3-CpG: 27/Downstream/18923
Upstream sequence
TCACTCAGAAAATGGAAGCAAAGAGGCCTATGTGACATTTGTTGATGCTATTGTGAGTGGTATTGTTTTATAAATTGTTGCTACTGCTTTTCTGAAAAAA
Downstream sequence
gcgtggtggcacatgcctgtaatcccagctacttaggaggctgaggtaggagaattgcttgaacctgggaggcggaggttgcagtgagccgggatcgcgc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate