Basic Information
VIS ID
TVIS10007627
Fusion event
HBV-PRSS43P integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr3
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
46825663/46784173 (Hg38)
End
46825663/46784173 (Hg38)
Orient
-
Location type
Intronic
Target gene
PRSS43P
Nearest miRNA
hsa-mir-12127/Upstream/1922192; hsa-let-7g/Downstream/1065382;
Nearest TSS
ENST00000440867/Upstream/39418; ENST00000490109/Downstream/28385;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/27200, chr3-CpG: 32/Downstream/28064
Nearby gene
PRSS45P(-39418) ; PRSS42P(+46231) ;
Upstream sequence
gcatgttgtagcattatcagaacttcattcctttttaaggccaagtcatattccattgtaggatctgccacatattgtttatggattcatcagttggtag
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate