Basic Information
VIS ID
TVIS10007630
Fusion event
HBV-TET2-AS1 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr4
Cytoband
q24
Reference genome
GRCh37/hg19
Start
106229460/105308303 (Hg38)
End
106229460/105308303 (Hg38)
Orient
-
Location type
Intronic
Target gene
TET2-AS1
Nearest miRNA
hsa-mir-12113/Upstream/3977889; hsa-mir-1243/Downstream/4180395;
Nearest TSS
ENST00000502981/Upstream/130240; ENST00000265154/Downstream/91333;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/161492, chr4-CpG: 82/Downstream/165091
Nearby gene
TET2(-28500) ; PPA2(+60774) ;
Upstream sequence
attctggatattagccctttgtcagatgagtaggttgcaaaaattttctcccatgttgtaggttgcctgttcactctgatggtagtttcttttgttgtgc
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate