VISDB Viral Integration Site DataBase

VIS ID

TVIS10007636

Fusion event

HBV-GLRA3 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

1962

Orient

+

Integrated sequence

TGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCT| |TCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTG

Chromosome

chr4

Cytoband

q34.1

Reference genome

Start

End

175704644/174783493 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-6733-5p ; hsa-mir-6739-5p ; hsa-mir-3153 ; hsa-mir-6077 ; hsa-mir-6088 ; hsa-mir-4770 ; hsa-mir-143-3p ; hsa-mir-5681a ; hsa-mir-9500 ; hsa-mir-5584-5p ; hsa-mir-6873-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p ; hsa-mir-574-5p ; hsa-mir-6818-5p ; hsa-mir-6867-5p ; hsa-mir-4311

Nearest miRNA

hsa-mir-12113/Upstream/359629; hsa-mir-1305/Downstream/7385800;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/260807, chr4-CpG: 26/Downstream/45686

Upstream sequence

ttcacactgaggaaactagtgattaggcaggctgggtaaattatctaagatctgaaatgatcaagtagaatttgaattcacatcttcctaacttcaaaac

Downstream sequence

ctgcacagcaaaagaaactaccatcagagtgaacaggcaacctacaaaatgggagaaaatttttgcaacctactcatctgacaaagggctaatatccaga