Basic Information
VIS ID
TVIS10007637
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|
Start
2744
Orient
+
Integrated sequence
GCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGAC| |ACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCT
Host Sequence
Chromosome
chr4
Cytoband
q35.2
Reference genome
GRCh37/hg19
Start
191044185/190123030 (Hg38)
End
191044185/190123030 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/5184590;
Nearest TSS
ENST00000502981/Upstream/58528; ENST00000616166/Downstream/50744;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/30576, chr4-CpG: 24/Downstream/50103
Nearby gene
DUX4L2(-30709) ;
Upstream sequence
ttcacactgaggaaactagtgattaggcaggctgggtaaattatctaagatctgaaatgatcaagtagaatttgaattcacatcttcctaacttcaaaac
Downstream sequence
ggttagggttagggttagggttagggttagggttagggttagggttcgggttcgggttcgggttcgggttcgggttcgggttcgggttcggNNNNNNNNN
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate