Basic Information
VIS ID
TVIS10007640
Fusion event
HBV-LOC101928721 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr4
Cytoband
p14
Reference genome
GRCh37/hg19
Start
37106109/37104487 (Hg38)
End
37106109/37104487 (Hg38)
Orient
+
Location type
Intronic
Target gene
LOC101928721
Nearest miRNA
hsa-mir-12113/Upstream/678059; hsa-mir-1243/Downstream/137423;
Nearest TSS
ENST00000502981/Upstream/25905; ENST00000309447/Downstream/139733;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/859720, chr4-CpG: 173/Downstream/139141
Nearby gene
DTHD1(-758731) ; MIR4801(+137423) ;
Upstream sequence
ATGATTTCTGATACAGATACATTTCCTAGAAAATGAGAGGGTTAAAGTTAAAGTGTATCATTAAGGCAGAATCCACTTAACTCTTAGAATTCAATGGAAA
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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