Basic Information
VIS ID
TVIS10007644
Fusion event
HBV-chr4 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr4
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
88485129/87563977 (Hg38)
End
88485129/87563977 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/263394; hsa-mir-1243/Downstream/11433410;
Nearest TSS
ENST00000502981/Upstream/32916; ENST00000399271/Downstream/44552;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/140970, chr4-CpG: 135/Downstream/443351
Nearby gene
SPARCL1(-34474) ; DSPP(+44552) ;
Nearest cancer related gene
SPARCL1(TSG, -34474) ;
Upstream sequence
CTCCACCATGTTTTCCTAGTGCAAGATTTTTCCTTTTCGCATATTTAAATTCATTTCATTGACAACAGGCATTGCAAACTCAATGATTTCTCTGTGCCAA
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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