Basic Information
VIS ID
TVIS10007648
Fusion event
HBV-LOC101929210 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
S protein|Polymerase|large S protein|middle S protein|
Start
504
Orient
+
Integrated sequence
CCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAATTCCAGGATCCTCAACAACC| |AGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTA
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
95039787/94118636 (Hg38)
End
95039787/94118636 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
LOC101929210
Nearest miRNA
hsa-mir-12113/Upstream/6818053; hsa-mir-1243/Downstream/4878751;
Nearest TSS
ENST00000502981/Upstream/289883; ENST00000506089/Downstream/88920;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/283477, chr4-CpG: 54/Downstream/88870
Nearby gene
ATOH1(-288645) ; SMARCAD1(+88972) ;
Upstream sequence
tttTGTTATGGTTTCACCATTTTGCCCCATCCTATGTTTAATCACTTGGAGTCACAAAAAGAAGGAATTGCCATGCTGATCTGTATGTATCTGAGGGTTT
Downstream sequence
atacagcttctcCATATGTACATAATTGGATAGTCATCACCTGTGGATTTTTTATATACTACTATCCAAATATTTTCCCTTGGAAGATTTCTCCTGGCAT
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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