Basic Information
VIS ID
TVIS10007649
Fusion event
HBV-LOC101929210 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
X protein|Polymerase|
Start
1538
Orient
+
Integrated sequence
GGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTT| |TACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCAAAT
Host Sequence
Chromosome
chr4
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
95046218/94125067 (Hg38)
End
95046218/94125067 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4E
Target gene
LOC101929210
Nearest miRNA
hsa-mir-12113/Upstream/6824484; hsa-mir-1243/Downstream/4872320;
Nearest TSS
ENST00000502981/Upstream/296314; ENST00000506089/Downstream/82489;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/289908, chr4-CpG: 54/Downstream/82439
Nearby gene
ATOH1(-295076) ; SMARCAD1(+82541) ;
Upstream sequence
AAGGAACCTTCACTTTAGTGTTGAACAAGAGTCTATTATATACTAGAAAAAACTTTACAAATTTACAGACTTCTGAAAGTTAAATGATGATTCTATTGTT
Downstream sequence
AAGTGTATCATTAAGGCAGAATCCACTTAACTCTTAGAATTCAATGGAAATAAGTTACAGGACAAATTATAGTATCTCTACCATACTTTCATCTTTCAGA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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