Basic Information
VIS ID
TVIS10007662
Fusion event
HBV-chr5 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr5
Cytoband
p15.31
Reference genome
GRCh37/hg19
Start
6970622/6970509 (Hg38)
End
6970622/6970509 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-4277/Upstream/142588; hsa-mir-10397/Downstream/1490416;
Nearest TSS
ENST00000502646/Upstream/36839; ENST00000512746/Downstream/355555;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/147345, chr5-CpG: 49/Downstream/319111
Nearby gene
MIR4278(-142588) ; MIR4454(+298794) ;
Upstream sequence
ttatataaaaattattttcatttaatgtttttattCCAACTGCAACACACTTTAAAATTTATAATAACCAAATGTTCACAAAATAATTTAAAAAGAATTT
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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