Basic Information
VIS ID
TVIS10007667
Fusion event
HBV-TBC1D32 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
121488806/121167660 (Hg38)
End
121488806/121167660 (Hg38)
Orient
+
Location type
Intronic
Target gene
TBC1D32
Nearest miRNA
hsa-mir-10398/Upstream/1152403; hsa-mir-1202/Downstream/5316971;
Nearest TSS
ENST00000381078/Upstream/4598; ENST00000282561/Downstream/69402;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/1817401, chr6-CpG: 31/Downstream/166865
Upstream sequence
CATTGTTTGTGACTGGAGTGCTACCTGAGTAAATTATCATGATTACATGAAAAGCAATTAAGAGAAGAAGGTCAAAGGACCAACCTCTAATCACTAAGTT
Downstream sequence
catgtccaaaacaccaaaagcaatggcaacaaaagccaaaattgacaaatgggatctaattaaactaaagagcttctgcacagcaaaagaaactaccatc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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