VISDB Viral Integration Site DataBase

VIS ID

TVIS10007670

Fusion event

HBV-EYA4 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2018

Orient

+

Integrated sequence

ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG

Chromosome

chr6

Cytoband

q23.2

Reference genome

Start

End

133791293/133470155 (Hg38)

Orient

-

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-203a-3p ; hsa-mir-27b-3p ; hsa-mir-224-5p ; hsa-mir-148b-3p ; hsa-mir-132-3p ; hsa-mir-128-3p ; hsa-mir-122-5p ; hsa-mir-181a-5p

Nearest miRNA

hsa-mir-10398/Upstream/1354892; hsa-mir-1202/Downstream/1509183;

Nearest TSS

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/227388, chr6-CpG: 43/Downstream/193828

Nearest cancer related gene

EYA4(TSG, No orient, 0)

Upstream sequence

ccctctttaagtaagtgacaaaactgaagtttgtccaggtccacagaactaataaaaatatttttataaatatctattataaattCAAGTTTCAAACTCT

Downstream sequence

gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa