Basic Information
VIS ID
TVIS10007671
Fusion event
HBV-chr6 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr6
Cytoband
q25.3
Reference genome
GRCh37/hg19
Start
159969311/159548279 (Hg38)
End
159969311/159548279 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10398/Upstream/783526; hsa-mir-1913/Downstream/6961075;
Nearest TSS
ENST00000381078/Upstream/164748; ENST00000494513/Downstream/40890;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/232338, chr6-CpG: 114/Downstream/144246
Nearby gene
FNDC1(-276171) ; SOD2(+130838) ;
Nearest cancer related gene
SOD2(TSG, +130838) ;
Upstream sequence
CTACATGTAGTGATTCCATAGGACAGATGTTTGCTCTGAGGTTGTAGCTTATTACATAATGTACCAATGGGGAAAATATTCATTTCAACAGTACGTGGCC
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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