Basic Information
VIS ID
TVIS10007675
Fusion event
HBV-MLIP integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
Polymerase|large S protein|middle S protein|
Start
151
Orient
+
Integrated sequence
TATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGC| |TGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCT
Host Sequence
Chromosome
chr6
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
54004514/54139716 (Hg38)
End
54004514/54139716 (Hg38)
Orient
-
Location type
Intronic
Target gene
MLIP
Nearest miRNA
hsa-mir-10398/Upstream/862645; hsa-mir-10524/Downstream/3250416;
Nearest TSS
ENST00000381078/Upstream/28206; ENST00000486436/Downstream/168143;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/343542, chr6-CpG: 74/Downstream/706639
Upstream sequence
GTTCTGCTTTTAAAAGAATAATCTAAAGCAATTGAAATTATACTTCAGTGACCACAGCAATCTCTTTTAAAGAGTAAGATGAAGTTAAATTAAAGGTCCC
Downstream sequence
gtaatgggtctgtttcggagctgacatttatgtaatgttaagtctgttgattcttgaagccatgttctttattactatcatttattgCTACAAAGAAATA
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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