Basic Information
VIS ID
TVIS10007681
Fusion event
HBV-LOC105375537 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2018
Orient
+
Integrated sequence
ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG
Host Sequence
Chromosome
chr7
Cytoband
q34
Reference genome
GRCh37/hg19
Start
140762881/141063081 (Hg38)
End
140762881/141063081 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375537
Nearest miRNA
hsa-mir-10399/Upstream/2018924; hsa-mir-11400/Downstream/1411446;
Nearest TSS
ENST00000635602/Upstream/47853; ENST00000563442/Downstream/11151;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/47938, chr7-CpG: 235/Downstream/9477
Nearby gene
MRPS33(-48100) ; TMEM178B(+11151) ;
Upstream sequence
tatgcaagcctagatgtgtttaaaacctatatggagaaagctataaaaagctcctgaaaggcacaaaagtacctacaacaaaaggaaaagatatgccata
Downstream sequence
gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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