Basic Information
VIS ID
TVIS10007688
Fusion event
HBV-chr7 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr7
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
99411691/99814068 (Hg38)
End
99411691/99814068 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA7F
Nearest miRNA
hsa-mir-10525/Upstream/404804; hsa-mir-10399/Downstream/279492;
Nearest TSS
ENST00000635602/Upstream/29803; ENST00000631161/Downstream/13945;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/196806, chr7-CpG: 76/Downstream/104911
Nearby gene
CYP3A4(-29880) ; CYP3A43(+13945) ;
Upstream sequence
tgtaccaccacacctggctaacttttgtatttttaatagagacggggtttcgcgatgttggccaggctagtcttgaactcctgacctcaggtgatccacc
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate