Basic Information
VIS ID
TVIS10007690
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2016
Orient
+
Integrated sequence
TTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTAT| |CGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGG
Host Sequence
Chromosome
chr8
Cytoband
q23.3
Reference genome
GRCh37/hg19
Start
114686300/113674071 (Hg38)
End
114686300/113674071 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-12123/Upstream/1030488; hsa-mir-10400/Downstream/3200657;
Nearest TSS
ENST00000518652/Upstream/58567; ENST00000519248/Downstream/607996;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/241215, chr8-CpG: 33/Downstream/1974134
Nearby gene
CSMD3(-237058) ; TRPS1(+1734424) ;
Upstream sequence
AATATACAATACATGAATAATTTATGTATTCATGCCACGAACAATTTCTTTCTTTAATTAAATTAAGGGGTTGGTGAGGATGGCAGTAGGAGCCAAGTTC
Downstream sequence
gacatgaagtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatcc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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