Basic Information
VIS ID
TVIS10007692
Fusion event
HBV-chr8 integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
2068
Orient
+
Integrated sequence
TTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCA| |GGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGT
Host Sequence
Chromosome
chr8
Cytoband
q24.22
Reference genome
GRCh37/hg19
Start
132125293/131113046 (Hg38)
End
132125293/131113046 (Hg38)
Orient
-
Location type
Intronic
Target gene
LOC105375759 ; LOC105375760
Nearest miRNA
hsa-mir-1204/Upstream/1104593; hsa-mir-10400/Downstream/1933435;
Nearest TSS
ENST00000518652/Upstream/70620; ENST00000519005/Downstream/31835;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/70543, chr8-CpG: 92/Downstream/790957
Nearby gene
ADCY8(-72458) ; EFR3A(+791063) ;
Upstream sequence
gcttttttttttttttttttaatctttgtagctttcttatttaggaataaaatgggaggcaggtttgcctgacatagtttccagcttgacttttcctttg
Downstream sequence
agatgcatagtttgcagatattttcttctattctgtgagttgtctctttagtttgttgattgtattctttgctgtgcagaagctttttaacttgatgtga
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
Curate