TOX _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10007697
Fusion event
HBV-TOX integration
Validated
No
Detection method
NGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2018
PubMed ID
30271481
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
precore/core protein|Core and e antigen|
Start
1958
Orient
+
Integrated sequence
CTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTT| |GCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCAT
Host Sequence
Chromosome
chr8
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
59832115/58919556 (Hg38)
End
59832115/58919556 (Hg38)
Orient
+
Location type
Intronic
Target gene
TOX
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-223-3p
Nearest miRNA
hsa-mir-124-1/Upstream/16023281; hsa-mir-10400/Downstream/2795232;
Nearest TSS
ENST00000518652/Upstream/259712; ENST00000523683/Downstream/199484;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/259589, chr8-CpG: 175/Downstream/198019
Upstream sequence
TGTTACTCATATCATTACTATTGTATTTAAGTACGACAAATACTAAAAATGAGAAAAATTGTAAAAAAAAGTTCAAATGCATAAAATAGGTAACGTATTA
Downstream sequence
aagatggattaaagatttaaacgttagacctaaaaccataaaaaccctagaagaaaacctaggcattaccattcaggacataggcgtgggcaaggacttc
Reference
Yang, L., et al. Molecular Characterization of HBV DNA Integration in Patients with Hepatitis and Hepatocellular Carcinoma. J Cancer ,2018,9(18): 3225-3235.
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