VISDB Viral Integration Site DataBase

VIS ID

TVIS10007701

Fusion event

HBV-LINGO2 integration

Validated

No

Detection method

NGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2018

PubMed ID

Virus name

HBV

Reference genome

Region type

precore/core protein|Core and e antigen|

Start

2018

Orient

+

Integrated sequence

ATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCG| |GGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTG

Chromosome

chr9

Cytoband

p21.1

Reference genome

Start

End

28112973/28112975 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-587 ; hsa-mir-7162-5p ; hsa-mir-516b-3p ; hsa-mir-516a-3p ; hsa-mir-2115-5p ; hsa-mir-1976 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-660-3p ; hsa-mir-5193

Nearest miRNA

hsa-mir-101-2/Upstream/6600790; hsa-let-7a-1/Downstream/750651;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/538986, chr9-CpG: 74/Downstream/1099198

Upstream sequence

gctggtctcgaactcttgacctcaggtggtccacccacctcaacctccctaagtgctgagattaTTTTAATCTTTGACAAGCCTCCACCTATTTGAGGTA

Downstream sequence

gtccttgcccacgcctatgtcctgaatggtaatgcctaggttttcttctagggtttttatggttttaggtctaacgtttaaatctttaatccatcttgaa